Understanding the reasons behind knee replacement failure is essential for maintaining long-term joint health. Specialists at KK Swara Super Speciality Hospital, Uppal, Hyderabad, explain that knee replacement surgery may fail due to several factors, including infection, loosening of the implant, improper alignment, wear of prosthetic components, nerve injury, or poor bone quality. Patient-related factors such as obesity, uncontrolled diabetes, insufficient rehabilitation, and participation in high-impact activities can also negatively influence outcomes. In addition, delayed identification of complications and issues related to surgical technique may increase the risk of failure. To minimize these risks, experts emphasize the importance of timely follow-ups, advanced surgical planning, and personalized rehabilitation programs. These measures significantly improve long-term mobility, implant longevity, and overall patient satisfaction.